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Prosecuting a murder case without a victim's body "is rare but not unheard of," but the key is having "sufficient evidence to show that the alleged victim is indeed dead," a Massachusetts criminal defense lawyer said.

Authorities now face that task in the disappearance of Ana Walshe, whose husband is charged with murdering the woman whose remains have not been found.

She was last seen during a New Year's celebration at her Cohasset, Massachusetts home, and there's still no sign of her. The Norfolk District Attorney's Office announced Tuesday that Brian Walshe is being charged with her murder.

Nathaniel Amendola, a criminal defense lawyer in Massachusetts who's been following the case closely, told Fox News Digital on Tuesday, before the murder charge was announced, that prosecutors would need to rely on other types of evidence to prove a death has occurred. 

BRIAN WALSHE CHARGED IN ANA WALSHE'S MURDER IN MASSACHUSETTS

Missing MA woman Ana Walshe smiles in selfie photo in front of hotel

Ana Walshe pictured in front of a Ritz Carlton hotel sign in August 2022. (Ana Walshe/Instagram)

"Think about a drug case. They want to prosecute two kilos of cocaine traffic, but they don't have the coke, then it's like what are we doing here? Where's the evidence? That's the body of the crime," Amendola said. 

That's the same with a murder trial without a body. The jury will want to know, where's Ana, he said. 

"Prosecutors are going to have a hard time," said Amendola, who stressed he was speaking hypothetically. "I don't mean to be macabre about this, but prosecutors can piece together evidence if they find body parts that can be tied to Ana.

"If they find head, and again I don't mean to be macabre about this, but that's evidence that she's deceased. But if they find a finger … how can you prove that she didn't lose a finger in a fight and she's still alive somewhere."

TIMELINE OF ANA WALSHE'S DISAPPEARANCE AND BRIAN WALSHE'S ARREST

brian and ana walshe posing for photo

Brian and Ana Walshe seen in September 2016. (Ana Walshe/Facebook)

That's the abridged version of the tricky nature of prosecuting a murder case without a body.

Behind the scenes, Amendola suspects authorities have been pressuring Brian Walshe to make a statement, and he's sure Walshe's lawyer is telling him to remain silent.

"A confession, for example, may help satisfy that burden, though the law requires that some additional evidence corroborates the confession," Amendola said. "As of right now, there’s no direct evidence that Ana Walshe is dead. But there may be some circumstantial evidence that she is."

Brian Walshe smiles outside of courthouse

Brian Walshe seen at Quincy District Court in connection to his wife, Ana Walshe's. disappearance.  (WBZ)

He said, for example, if the blood found in the basement of the Walshes' home, as well as a broken knife, is positively identified as Ana's, "one can infer that it got there because she was cut by the knife."

"If the authorities can piece enough of this type of evidence together, they may be able to show, circumstantially, that Ana is dead," Amendola said.

ANA WALSHE CASE: POLICE LOGS RAISE QUESTIONS, SHED LIGHT ON DETAILS OF MISSING WOMAN

That's what Daniel Bibb, a former Manhattan assistant district attorney-turned criminal defense lawyer, had to do when he prosecuted Dr. Robert Bierenbaum for the 1985 murder of his wife, Gail Katz.

Bibb called it "the toughest case of our career" when he spoke to Fox News Digital last August about prosecuting a homicide when the victim's body has not been found. He weighed in on the challenges of that type of case amid last summer's trial in Kristin Smart's disappearance, which led to Paul Flores being convicted of murder.

Ana and Brian Walshe take a selfie with friend in a restaurant

Ana and Brian Walshe pictured in a 2015 Facebook post.  (Ana Walshe/Facebook)

"There were two aspects to building this case," Bibb said about the Katz case. "The first was, can we prove that she is deceased? And looking at all evidence – not only the evidence as it existed then, but the evidence that was developed. There are two issues here: Is she dead, and who killed her?

"The problem was, could we prove it beyond a reasonable doubt? And when we were done investigating and we … sat down and went over it piece-by-piece, we came to the conclusion that she was dead, and he did it."

Bibb and his team secured a conviction against Bierenbaum in October 2000, and 20 years later, Bierenbaum confessed to the murder during a parole board hearing. 

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Brian Walshe was arrested for allegedly lying to police about his whereabouts on Jan. 1 and Jan. 2 while police were searching for his wife, according to the probable cause affidavit for his arrest. 

Investigators search Walshe property

Massachusetts State Police troopers and other officials searched the property, backyard, pool and surrounding area of missing woman Ana Walshe's home in Cohasset on Saturday, Jan. 7, 2023. (David McGlynn for Fox News Digital)

It took three days for anyone to report Ana Walshe missing, according to authorities. 

Search warrants were executed last Thursday and then impounded, which means they were returned and not available to the public, a member of the Quincy District Court told Fox News Digital.

There's no plan to unseal them, the court said last week, so it's not yet known where the warrants were executed and what was recovered. 

brian and ana walshe posing for photo

Brian and Ana Walshe seen in September 2016. (Ana Walshe/Facebook)

In the days between Ana’s disappearance and the missing person’s report, Brian Walshe allegedly lied about his own whereabouts. Investigators said Walshe told investigators he traveled to stores, such as CVS and Whole Foods, where he might not have actually been.

ANA WALSHE INVESTIGATION UNCOVERS HATCHET, HACKSAW FOUND IN TRASH FACILITY: REPORT

But he allegedly neglected to mention that he spent about $450 in cash buying cleaning supplies from a Rockland, Massachusetts, Home Depot. 

Investigators also discovered blood and a bloody, damaged knife in the basement of the couple’s home, prosecutors said. Police also reportedly found bloody trash bags, a hatchet and a hacksaw at a waste facility about an hour from the family's home.

They also traced Ana’s cellphone to the area of the family’s Cohasset home on Jan. 1, and approximately 0.7 miles away from the home on Jan. 2, according to officials and a police log. 

Brian’s cellphone pinged in other parts of Massachusetts, such as Brockton and Abington, despite his lack of permission to be in the areas under the terms of his home confinement. The convicted art swindler was under home confinement as he awaits sentencing for selling bogus Andy Warhol paintings.

Ana Walshe and Brian Walshe on their wedding day

Brian and Ana Walshe raise a toast on their wedding day in the lounge of L'Espalier in Boston, Massachusetts on Monday, December 21, 2015. (Obtained by Fox News Digital)

Officials previously revealed that investigators recovered evidence when they appeared to have removed — and then replaced — a dumpster taken from Brian Walshe's mother's Swampscott home, located nearly 35 miles from the couple's home. 

And a recent CNN report described how Walshe had conducted internet searches for "how to dispose of a 115-pound woman's body" and how to dismember a body.

Brian Walshe was arrested on Jan. 8 and charged with misleading a police investigation. 

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Police said the charge stemmed from Walshe's alleged "intentional, willful and direct responses to questions about his whereabouts on the days of Sunday, January 1, 2023 and Monday, January 2, 2023." 

They further called it, "a clear attempt to mislead and delay investigators."