Philadelphia Eagles quarterback Jalen Hurts is among the favorites to win the NFL MVP award along with fellow quarterbacks Brock Purdy, Dak Prescott, Lamar Jackson, Patrick Mahomes and Tua Tagovailoa.

Hurts’ odds took a hit as the Eagles lost to Purdy and the San Francisco 49ers, 42-19, on Sunday. Hurts was 26-for-45 with 298 yards, a touchdown pass and a rushing touchdown. It was enough for at least one NFL analyst to call for Philadelphia to make a change at starting quarterback.

CLICK HERE FOR MORE SPORTS COVERAGE ON foxnews.1eye.us

Jalen Hurts kneels

Eagles quarterback Jalen Hurts kneels before the San Francisco 49ers game on Dec. 3, 2023, at Lincoln Financial Field in Philadelphia. (Kyle Ross/Icon Sportswire via Getty Images)

David Carr, a former quarterback for the Houston Texans and New York Giants, said Tuesday the Eagles should replace Hurts with Marcus Mariota. Carr cited Hurts allegedly being "uncomfortable" reading defenses while in the pocket as well as his health.

"Clearly, Jalen isn’t comfortable reading through a defense in a drop back pass scenario. Some would say he’s not even good at it," Carr said. "I think when you look at this team, you have to have a serious conversation, if you’re Philly. And you have to say, ‘Is it better for us to play Marcus Mariota right now and get Jalen really healthy,’ because I would argue it doesn’t matter if they’re the No. 1 seed. If the 49ers come into Philly again, they do not care.

FROM OUTKICK: TREVOR LAWRENCE SPRAINS ANKLE AND JAGUARS HOPEFUL MRI SHOWS HE’S NOT DONE FOR SEASON

Marcus Mariota vs Chiefs

Marcus Mariota of the Philadelphia Eagles warms up before the Chiefs game at GEHA Field at Arrowhead Stadium on Nov. 20, 2023, in Kansas City, Missouri. (Perry Knotts/Getty Images)

"Put Marcus in there, win a couple of games, maybe you have the No. 1 seed still, you might have it," Carr continued. "I’d say [Mariota] is better at playing quarterback for the Philadelphia Eagles right now. Right now, he’d be more productive."

Hurts left the game Sunday for a few plays and the team inserted Mariota. Hurts came back, but Philadelphia still came up short.

Carr added that these are the types of conversations Nick Sirianni has to have if he has a "big picture mentality."

TREVOR LAWRENCE RETURN UP IN THE AIR AFTER JAGUARS CONFIRM HIGH ANKLE SPRAIN

Everybody in the NFL is banged up through 13 weeks of the season, but quarterbacks have dropped like flies. Derek Carr, Trevor Lawrence and Kenny Pickett left their games during Week 13. It followed Joe Burrow and Deshaun Watson being lost for the season.

Aaron Rodgers, Daniel Jones and Anthony Richardson were lost for the season. Jimmy Garoppolo, Justin Fields and Matthew Stafford also missed time with injuries.

Jalen Hurts looks

Jalen Hurts of the Eagles during the San Francisco 49ers game at Lincoln Financial Field on Dec. 3, 2023, in Philadelphia. (Mitchell Leff/Getty Images)

GET FOX BUSINESS ON THE GO BY CLICKING HERE

The Super Bowl winner will be the team that stays healthy enough to get through another month.

Follow Fox News Digital’s sports coverage on X and subscribe to the Fox News Sports Huddle newsletter.