California Gov. Gavin Newsom on Thursday issued a statewide order mandating the use of facemasks in public, as more counties reconsider their regulations and the state continues to experience an increase in coronavirus-related hospitalizations as businesses reopen.

“Science shows that face coverings and masks work,” Newsom said in a statement announcing the order. “They are critical to keeping those who are around you safe, keeping businesses open and restarting our economy.”

The order comes as California broadly reopens the economy; in most counties, people can now shop, dine in at restaurants, get their hair done and go to church, among other things. Meanwhile, coronavirus cases are increasing, something the state says is expected as more people get tested. More than 3,400 people were in the hospital as of Wednesday, the most patients hospitalized since April.

Overall there have been 157,000 reported cases in the state, with more than 5,200 deaths as of Thursday.

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The order will require people to wear masks when inside or in line for any indoor public spaces, in health care settings like hospitals and pharmacies, while waiting for or riding public transportation and in outdoor spaces where it's not possible to stay six feet apart from other people.

Until now, the Democratic governor had let local governments decide whether to mandate masks, an issue that's become politically fraught as some Americans resist orders to wear them. He said he's issuing the order now because too many people are going out in public without face coverings as businesses, restaurants and other sectors of the economy reopen.

There has been widespread pushback from the more conservative areas of the state over facemasks, with Orange County most recently dropping its rule for wearing them.

Orange County's public health officer resigned last week after she faced threats over her order that people wear masks, and the county sheriff said he wouldn't enforce it. Los Angeles County requires people to wear masks whenever they are outside their homes, as do San Francisco and Santa Clara counties.

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The state's news release didn't say how it would enforce the order or what the penalty would be for people who don't comply. The order also applies to workplaces where people interact with the public, prepare or package food and share common spaces like hallways and elevators. Office workers would have to wear masks if they can't physically distance.

The order includes several exceptions, including for outdoor recreation and exercise such as walking, hiking, running or bicycling. But if people are doing such activities and cannot stay 6 feet apart from others, the state says they should wear masks.

Other exceptions include: Children under 2, people with medical conditions that prevent them from wearing a mask, people who are hearing impaired or communicate with people who are hearing impaired and people obtaining receiving treatments on their nose and mouth. There's also an exception if wearing a face covering would violate workplace safety guidelines.

People eating out at restaurants wouldn't have to wear masks when they are eating and drinking as long as they are 6 feet away from others.

The Associated Press contributed to this report.