The Biden administration is asking a federal court to lift an order that blocked its rule mandating that larger employers require workers to get COVID-19 vaccines or submit to regular testing.

The request, filed Monday, comes after the Fifth Circuit Court of Appeals ruled in favor of a group of businesses to halt the order, citing "grave statutory and constitutional issues." The ruling put the mandate on hold until pending litigation could be heard.

But the administration claims that the companies that won the emergency stay were not claiming a major prospect of harm from the rule until December, arguing that the court should allow the mandate to proceed.

Joe Biden

President Joe Biden (AP Photo/Andrew Harnik)

HOUSE REPUBLICANS MOVE TO STALL BIDEN'S VACCINE MANDATE

"Accordingly, there is no need to address petitioners’ stay motions now, and the Court should lift its administrative stay and allow this matter to proceed under the process that Congress set forth for judicial review of OSHA standards," lawyers for the administration argued in a federal appeals court.

The Occupational Safety and Health Administration regulation is set to apply to employers with at least 100 workers, creating a temporary rule that will require those companies to mandate workers be vaccinated against COVID-19 or submit to regular testing. A deadline for companies to comply with the regulation was then set for Jan. 4.

But the mandate was the subject of several lawsuits from states, companies and business groups, who argue it could hinder the economic recovery just as the holiday season goes into high gear.

President Joe Biden receives a COVID-19 booster shot.

President Joe Biden receives a COVID-19 booster shot. (Evan Vucci/Associated Press)

Meanwhile, the Biden administration has encouraged large employers to comply with the mandate as the case makes its way through the court system.

"We think people should not wait," White House deputy press secretary Karine Jean-Pierre said. "Do not wait to take actions that will keep your workplace safe. It is important and critical to do, and waiting to get more people vaccinated will lead to more outbreaks and sickness.

"The Department of Labor has a responsibility to keep workers safe and the legal authority to do so," Jean-Pierre added.

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President Biden.

President Biden. (AP Photo/Alex Brandon)

President Biden initially announced the new mandate in September, saying at the time that it was a critical step to increase the number of vaccinated Americans.

"We've been patient, but our patience is wearing thin, and your refusal has cost all of us," Biden said at the time. "While America is in much better shape than it was seven months ago when I took office … we're in a tough stretch, and it could last for a while."